Dr Johnson was about as confused as we are.
Of course you can disregard etymology completely and decide to spell everything with —ise or —ize, and this is happening. The great majority are ad hoc neologisms, mongrels, all hybrid vigour and no pedigree. In other relevant fields, such as chemistry, the term refers to the act or process of forming a complex substance by combining or integrating two or more chemical entities, especially through a chemical reaction.
Words like advertiseadvisecomprisecompromisedespisedeviseexerciseimproviserevisesurprisetelevise. In biochemistry, it refers to the production of an organic compound in a living thing, especially as aided by enzymes.
Words which derive from Greek via Latin take the —ize ending to show their link to the Greek ending —izein. It is the odd-man-out in our alphabet. But Johnson was no great stickler for consistency.